Abstract
In three patients with monoclonal IgM antibodies to myelin-associated glycoprotein and a demyelinating neuropathy, the human monoclonal antibodies and HNK1, a mouse monoclonal antibody against human natural killer cells, reacted with the same region of myelin-associated glycoprotein. In these three patients there was a pronounced decrease in the number of circulating HNK1-positive cells. Taken together, these findings provide evidence that a cross-reactive cell surface antigen may be involved in an autoimmune response directed simultaneously against the nervous system and the immune system.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Animals
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Antibodies, Monoclonal / immunology
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Antigens, Surface / immunology
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Autoimmune Diseases / etiology*
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Cross Reactions
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Demyelinating Diseases / etiology
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Demyelinating Diseases / immunology*
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Epitopes / analysis
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Humans
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Immunoglobulin M / immunology
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Killer Cells, Natural / immunology*
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Male
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Mice
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Middle Aged
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Myelin Proteins / immunology
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Myelin Sheath / immunology*
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Myelin-Associated Glycoprotein
Substances
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Antibodies, Monoclonal
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Antigens, Surface
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Epitopes
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Immunoglobulin M
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Myelin Proteins
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Myelin-Associated Glycoprotein