The effects of adriamycin in vitro and in vivo on hepatic microsomal drug-metabolizing enzymes: role of microsomal lipid peroxidation

Toxicol Appl Pharmacol. 1981 Dec;61(3):313-25. doi: 10.1016/0041-008x(81)90352-5.
No abstract available

MeSH terms

  • Aminopyrine N-Demethylase / antagonists & inhibitors
  • Animals
  • Cytochrome P-450 Enzyme Inhibitors
  • Doxorubicin / pharmacology*
  • Glucose-6-Phosphatase / metabolism
  • Glucuronosyltransferase / metabolism
  • In Vitro Techniques
  • Lipid Peroxides / metabolism*
  • Male
  • Microsomes, Liver / enzymology*
  • NADPH-Ferrihemoprotein Reductase / metabolism
  • Rats
  • Rats, Inbred Strains

Substances

  • Cytochrome P-450 Enzyme Inhibitors
  • Lipid Peroxides
  • Doxorubicin
  • Aminopyrine N-Demethylase
  • NADPH-Ferrihemoprotein Reductase
  • Glucuronosyltransferase
  • Glucose-6-Phosphatase