Abstract
In soft tissues outside the central nervous system, S-100 protein is found normally only in Schwann cells. Using the peroxidase-antiperoxidase immunohistochemical method S-100 was also found in tumors derived from Schwann cells and melanocytes, including neurofibromas, neurilemomas, granular cell myoblastomas, cutaneous nevi, and malignant melanomas. S-100 was not detected in malignant Schwannomas, neuroblastomas, oat cell carcinomas, medullary carcinomas of the thyroid, paragangliomas, or meningiomas. S-100 was also absent from neoplasms of soft tissues not usually considered to arise from cells of neural crest origin. S-100 appears to be a useful marker for identifying neoplasms derived from Schwann cells and melanocytes.
MeSH terms
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Histocytochemistry
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Humans
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Immunoenzyme Techniques
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Melanocytes / analysis*
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Melanoma / analysis
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Melanoma / pathology
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Neoplasm Proteins / analysis
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Neoplasms, Muscle Tissue / analysis
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Neoplasms, Muscle Tissue / pathology
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Nerve Tissue Proteins / analysis*
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Neurilemmoma / analysis
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Neurilemmoma / pathology
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Neuroblastoma / analysis
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Neuroblastoma / pathology
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Neuroma, Acoustic / analysis
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Neuroma, Acoustic / pathology
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Nevus / analysis
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Nevus / pathology
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Rhabdomyosarcoma / analysis
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Rhabdomyosarcoma / pathology
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S100 Proteins / analysis*
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Schwann Cells / analysis*
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Skin Neoplasms / analysis
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Skin Neoplasms / pathology
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Soft Tissue Neoplasms / analysis*
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Soft Tissue Neoplasms / pathology
Substances
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Neoplasm Proteins
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Nerve Tissue Proteins
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S100 Proteins