Metabolic abnormalities in diabetic peripheral nerve: relation to impaired function

Metabolism. 1983 Jul;32(7 Suppl 1):118-23. doi: 10.1016/s0026-0495(83)80024-9.

Abstract

An hypothesis is presented relating several well-defined metabolic abnormalities in diabetic peripheral nerve to impaired peripheral nerve function by a sodium-potassium ATPase mechanism. It is proposed that this hypothesis be tested in the most well-defined animal model for human insulin deficiency diabetes currently available--the BB diabetic rat.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Diabetes Mellitus, Experimental / metabolism*
  • Diabetes Mellitus, Type 1 / metabolism*
  • Energy Metabolism
  • Female
  • Glucose / metabolism
  • Hyperglycemia / metabolism
  • Inositol / metabolism
  • Male
  • Peripheral Nerves / enzymology
  • Peripheral Nerves / metabolism*
  • Phosphocreatine / metabolism
  • Rats
  • Rats, Inbred Strains
  • Sodium-Potassium-Exchanging ATPase / metabolism

Substances

  • Phosphocreatine
  • Inositol
  • Sodium-Potassium-Exchanging ATPase
  • Glucose