Abstract
An hypothesis is presented relating several well-defined metabolic abnormalities in diabetic peripheral nerve to impaired peripheral nerve function by a sodium-potassium ATPase mechanism. It is proposed that this hypothesis be tested in the most well-defined animal model for human insulin deficiency diabetes currently available--the BB diabetic rat.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Diabetes Mellitus, Experimental / metabolism*
-
Diabetes Mellitus, Type 1 / metabolism*
-
Energy Metabolism
-
Female
-
Glucose / metabolism
-
Hyperglycemia / metabolism
-
Inositol / metabolism
-
Male
-
Peripheral Nerves / enzymology
-
Peripheral Nerves / metabolism*
-
Phosphocreatine / metabolism
-
Rats
-
Rats, Inbred Strains
-
Sodium-Potassium-Exchanging ATPase / metabolism
Substances
-
Phosphocreatine
-
Inositol
-
Sodium-Potassium-Exchanging ATPase
-
Glucose