Evidence of a covalent linkage in the adriamycin-cardiolipin complex induced by adriamycin-mediated electron transport

E Goormaghtigh; J M Ruysschaert

Evidence of a covalent linkage in the adriamycin-cardiolipin complex induced by adriamycin-mediated electron transport

Res Commun Chem Pathol Pharmacol. 1983 Oct;42(1):149-52.

Authors

E Goormaghtigh, J M Ruysschaert

PMID: 6316434

Abstract

Adriamycin mediated electron transport between NADH and cytochrome c results in the formation of a new linkage between adriamycin and cardiolipin. Infrared study of this complex demonstrates the appearance of new covalent linkages.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cardiolipins / metabolism*
Cytochrome c Group / metabolism*
Doxorubicin / metabolism*
Electron Transport
NAD / metabolism*
Spectrophotometry, Infrared

Substances

Cardiolipins
Cytochrome c Group
NAD
Doxorubicin