Abstract
Fifty-five Caucasoid patients with polymyalgia rheumatica or giant cell arteritis were typed for HLA, A, B, C and DR locus antigens. In the total patient group, DR4 had a significantly increased frequency. The prevalence of CW3 and CW6 was also significantly increased, the rise of CW3 possibly being attributable to its well-documented linkage disequilibrium with DR4. The rise in CW6 cannot be attributed to its known linkage disequilibrium with DR7.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Genes, MHC Class II*
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Genetic Linkage
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Giant Cell Arteritis / genetics*
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HLA Antigens / genetics*
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HLA-A Antigens
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HLA-B Antigens
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HLA-C Antigens
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HLA-DR4 Antigen
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HLA-DR7 Antigen
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Histocompatibility Antigens Class II*
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Histocompatibility Testing
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Humans
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Polymyalgia Rheumatica / genetics*
Substances
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HLA Antigens
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HLA-A Antigens
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HLA-B Antigens
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HLA-C Antigens
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HLA-DR4 Antigen
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HLA-DR7 Antigen
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Histocompatibility Antigens Class II