During a six-month period, 552 infants were admitted to a level III Neonatal Intensive Care Unit (NICU) and four level II units. Of the 953 cross matches of blood components requested from the blood bank, 83% were administered. Forty-four percent of the infants received multiple blood transfusions from multiple blood donors (mean 3.9 donors, range two to 11). Thirty-one percent received multiple transfusions from only one donor. The mean total volume of blood given was 22.5 ml (range 3 to 120 ml), exclusive of blood used for exchange transfusions. Seventy percent of the blood components were given to infants weighing less than 2,500 gm, and 44% were given to infants weighing less than 1,500 gm. Hospitals having only level II units must have the same blood banking facilities as hospitals with level III units, since 21% of the infants given transfusion received the blood component while receiving level II care.