I report the successful treatment of severe infantile opiate poisoning with continuous naloxone infusions. Two infants, one aged 12 months and the other 3 days, were intoxicated with 100 mg normethadone and 5 mg morphine, respectively. They were given constant infusions of 0.04 and 0.16 mg/kg/hr for 2 1/2 and 5 days, respectively. Continuous naloxone infusion should be considered in the management of severe opiate poisoning.