[Non-extractible residues of aryl-14C-albendazole in sheep]

Ann Rech Vet. 1983;14(1):65-70.
[Article in French]

Abstract

The location of the intractable residues of 14C-ring labelled-albendazole has been investigated in the sheep. Numerous biochemical compounds have been isolated: pulmonary CO2, blood dextrose, glycogen, triglycerides, cholesterol, hemoglobin, plasmatic, cytosolic and microsomal proteins, nucleic acids . . . No incorporation into intermediary metabolisms has been put into evidence. On the contrary, a significant covalently bound radioactivity has been observed on hepatic and plasmatic proteins. No covalent binding to hepatic DNA seems to be produced.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthelmintics / metabolism*
  • Biotransformation
  • Blood Proteins / metabolism
  • Chemical Phenomena
  • Chemistry
  • Female
  • Liver / metabolism
  • Protein Binding
  • Sheep / metabolism*
  • Subcellular Fractions / metabolism

Substances

  • Anthelmintics
  • Blood Proteins