Chlordiazepoxide increases the force of two topographically distinct operant responses in rats

Pharmacol Biochem Behav. 1983 Nov;19(5):787-90. doi: 10.1016/0091-3057(83)90081-3.

Abstract

By using operant conditioning techniques one group of 8 rats was trained to reach through a hole in the wall of an operant chamber, and to exert downward responses on a force-sensing circular disk. Eight other rats learned to reach through the hole and grasp and pull toward them a wire bail attached to a force transducer. Both behaviors were maintained on a fixed ratio 20 schedule of water reinforcement. The effects of chlordiazepoxide (CDP, 2.5, 5.0, 10.0 mg/kg) on response force and rate were assessed for both groups. CDP significantly increased response force in a dose-related manner in both groups; regardless of topography, response rate was little affected by the 2.5- and 5.0 mg/kg doses but was decreased by the highest dose. Results were discussed in terms of CDP's antipunishment and neuromuscular effects.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chlordiazepoxide / pharmacology*
  • Conditioning, Operant / drug effects*
  • Dose-Response Relationship, Drug
  • Male
  • Rats
  • Rats, Inbred Strains
  • Reaction Time / drug effects

Substances

  • Chlordiazepoxide