Ethnic variation of genetic disease: roles of drift for recessive lethal genes

Am J Hum Genet. 1978 May;30(3):262-70.

Abstract

Using Wright's distribution of gene frequencies for a recessive lethal gene, a method is given to analyze the probability that any particular gene frequency is greater than a given threshold gene frequency. The method is introduced to analyze the plausibility of drift for explaining observed data.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Computers
  • Female
  • Gene Frequency*
  • Genes, Lethal*
  • Genes, Recessive*
  • Humans
  • Lipidoses / genetics
  • Male
  • Mathematics
  • Models, Biological
  • Racial Groups*