Behavioral effects of dopamine agonists across the estrous cycle in rats

Psychopharmacology (Berl). 1980;71(2):147-51. doi: 10.1007/BF00434403.

Abstract

The effects of apomorphine upon stereotypy and bromocriptine upon wheel running and intracranial reward were examined across the estrous cycle of female rats. Apomorphine elicited sterotypy in a dose-related fashion, but sterotypy was not reliably or systematically altered by estrous conditions. On the other hand, wheel running was augmented by bromocriptine in an estrous-specific fashion. Self-stimulation was increased by bromocriptine but this was not related to estrous cyclicity. These findings provide evidence for possible behavioral and motivational specificity of dopamine (DA) receptor-related estrous changes.

MeSH terms

  • Animals
  • Apomorphine / pharmacology*
  • Behavior, Animal / drug effects*
  • Bromocriptine / pharmacology*
  • Estrus*
  • Female
  • Humans
  • Motor Activity / drug effects
  • Pregnancy
  • Rats
  • Self Stimulation / drug effects
  • Stereotyped Behavior / drug effects

Substances

  • Bromocriptine
  • Apomorphine