Dose-dependent modification of 1,1-dichloroethylene toxicity by acetone

Toxicol Lett. 1983 Apr;16(1-2):145-52. doi: 10.1016/0378-4274(83)90023-1.

Abstract

The ability of acetone to potentiate the toxicity of 1,1-dichloroethylene (DCE) in male rats was investigated. A biphasic potentiation of DCE-induced hepatotoxicity was observed; low doses (5 and 10 mmol/kg, p.o.) of acetone were active, whereas higher doses (15 and 30 mmol/kg) were not. Nephrotoxicity was not affected.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetone / toxicity*
  • Alanine Transaminase / blood
  • Animals
  • Blood Urea Nitrogen
  • Chemical and Drug Induced Liver Injury*
  • Dichloroethylenes / toxicity*
  • Drug Synergism
  • Hydrocarbons, Chlorinated / toxicity*
  • Kidney Diseases / chemically induced*
  • Male
  • Organ Size / drug effects
  • Ornithine Carbamoyltransferase / blood
  • Rats
  • Rats, Inbred Strains
  • Tetraethylammonium Compounds / metabolism
  • p-Aminohippuric Acid / metabolism

Substances

  • Dichloroethylenes
  • Hydrocarbons, Chlorinated
  • Tetraethylammonium Compounds
  • Acetone
  • vinylidene chloride
  • Ornithine Carbamoyltransferase
  • Alanine Transaminase
  • p-Aminohippuric Acid