Cytochrome P-450 dependent monooxygenase activity in rat nasal epithelial membranes

Toxicol Lett. 1982 Mar;10(4):417-22. doi: 10.1016/0378-4274(82)90240-5.

Abstract

Cytochrome P-450 was found in nasal epithelial membranes (NEM) of the rat. The quantity was 12% that of liver on a per mg of microsomal protein basis and 1.6 times that of lung on the same basis. Metabolism of p-nitroanisole was faster by microsomes from NEM than by microsomes from liver or lungs while the metabolism rate of aniline by microsomes from NEM was between that of microsomes from liver and lung.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cytochrome P-450 Enzyme System / metabolism*
  • Epithelium / enzymology
  • Liver / enzymology
  • Lung / enzymology
  • Male
  • Microsomes / enzymology
  • Mixed Function Oxygenases / metabolism*
  • Nasal Mucosa / enzymology*
  • Oxidoreductases / metabolism*
  • Rats
  • Rats, Inbred F344

Substances

  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • Oxidoreductases