The clinical and fluorescein angiographic features of seven patients with unilateral, large retinal vessels supplying or draining the macular region, both inferior and superior to the horizontal raphe, are described. All patients had good vision, although two patients also had a concomitant foveolar cyst in the involved eye. Four of the seven eyes had small perifoveolar arteriovenous communications, while three eyes did not. Four eyes also showed abnormal areas of retinal capillary nonperfusion. In addition, delayed drainage of dye from the enlarged vessels was a commonly encountered feature. It is suggested that these congenital anomalies be referred to as retinal macrovessels.