Abstract
The definitive identification of the first lignans to be found in humans and animals is described. Gas chromatography--mass spectrometry, n.m.r. spectroscopy, i.r. spectroscopy and chemical techniques were employed to establish the structures of two lignans as trans-2,3-bis(3-hydroxybenzyl)-gamma-butyrolactone and 2,3-bis(3-hydroxybenzyl)butane-1,4-diol. Both compounds are essetially racemic. Evidence was also found for several methoxy analogues of these lignans in the vervet monkey.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / analogs & derivatives
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4-Butyrolactone / isolation & purification
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4-Butyrolactone / urine*
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Animals
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Butylene Glycols / isolation & purification
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Butylene Glycols / urine*
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Chemical Phenomena
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Chemistry
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Chlorocebus aethiops
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Chromatography, Gas
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Chromatography, Thin Layer
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Female
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Furans / urine*
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Gas Chromatography-Mass Spectrometry
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Humans
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Lignans*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Pregnancy
Substances
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Butylene Glycols
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Furans
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Lignans
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2,3-bis(3'-hydroxybenzyl)butane-1,4-diol
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4-Butyrolactone
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2,3-bis(3'-hydroxybenzyl)butyrolactone