Immunosuppressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat

L J Moia; H Matsui; G A de Barros; K Tomizawa; K Miyamoto; Y Kuwata; M Tokuda; T Itano; O Hatase

doi:10.1016/0006-8993(94)91138-x

Immunosuppressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat

Brain Res. 1994 Jun 20;648(2):337-41. doi: 10.1016/0006-8993(94)91138-x.

Authors

L J Moia¹, H Matsui, G A de Barros, K Tomizawa, K Miyamoto, Y Kuwata, M Tokuda, T Itano, O Hatase

Affiliation

¹ Department of Physiology, Kagawa Medical School, Japan.

PMID: 7522929
DOI: 10.1016/0006-8993(94)91138-x

Abstract

Calcineurin (CaN) immunoreactivity and content increased markedly in kindled rat brain, and this increment was due to CaN in the membrane fraction. Investigation of the effects of cyclosporin A and FK506 (immunosuppressants which inhibit CaN activity in T lymphocytes) in the kindling phenomena showed that the kindling stage progression was reversibly blocked by these drugs. These findings suggest that calcineurin may play an essential role in acquiring epileptogenesis in kindling.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amygdala / physiology*
Animals
Calcineurin
Calmodulin-Binding Proteins / antagonists & inhibitors*
Calmodulin-Binding Proteins / metabolism
Cerebral Cortex / drug effects
Cerebral Cortex / metabolism
Cyclosporine / pharmacology
Densitometry
Epilepsy / physiopathology
Epilepsy / prevention & control*
Hippocampus / drug effects
Hippocampus / metabolism
Immunohistochemistry
Immunosuppressive Agents / pharmacology*
Kindling, Neurologic / physiology*
Male
Phosphoprotein Phosphatases / antagonists & inhibitors*
Phosphoprotein Phosphatases / metabolism
Rats
Rats, Sprague-Dawley
Tacrolimus / pharmacology

Substances

Calmodulin-Binding Proteins
Immunosuppressive Agents
Cyclosporine
Calcineurin
Phosphoprotein Phosphatases
Tacrolimus