Abstract
Adenovirus encodes numerous products that counteract host defenses. A virus-encoded RNA, VA RNA1, prevents interferon-mediated shut-off of protein synthesis. Other protein products inhibit interferon-induced gene transcription, prevent cell killing by cytotoxic T cells or block apoptosis, and three sets of proteins independently block the cytolysis and inflammation induced by tumor necrosis factor. Studies of these factors are providing insights into viral pathogenesis.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adenovirus Infections, Human / immunology
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Adenovirus Infections, Human / virology*
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Adenoviruses, Human / pathogenicity*
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Animals
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Apoptosis
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Humans
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Immunity, Innate / immunology
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Interferons / antagonists & inhibitors
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Interferons / genetics
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Interferons / physiology
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T-Lymphocytes, Cytotoxic / physiology
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
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Tumor Necrosis Factor-alpha / physiology
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Viral Proteins / biosynthesis
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Viral Proteins / genetics
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Viral Proteins / physiology*
Substances
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Tumor Necrosis Factor-alpha
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Viral Proteins
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Interferons