Levels of hepatitis C virus (HCV) RNA in serum and their relationship to levels of immunoglobulin M and G antibodies against HCV core protein

M Chen; A Sönnerborg; M Sällberg

doi:10.1128/jcm.33.3.778-780.1995

Levels of hepatitis C virus (HCV) RNA in serum and their relationship to levels of immunoglobulin M and G antibodies against HCV core protein

J Clin Microbiol. 1995 Mar;33(3):778-80. doi: 10.1128/jcm.33.3.778-780.1995.

Authors

M Chen¹, A Sönnerborg, M Sällberg

Affiliation

¹ Division of Clinical Virology, Karolinska Institute, Huddinge University Hospital, Sweden.

Abstract

The presence and levels of hepatitis C virus (HCV) RNA and immunoglobulin M (IgM) and IgG antibodies against the virus core protein were determined in 449 serum specimens. Despite the fact that a relationship between the presence, but not the levels, of HCV RNA and HCV IgM was observed, the significance of HCV core IgM assays seems limited.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Hepacivirus / genetics
Hepacivirus / immunology
Hepacivirus / isolation & purification*
Hepatitis Antibodies / blood*
Hepatitis C / immunology
Hepatitis C / virology
Hepatitis C Antibodies
Humans
Immunoglobulin G / blood
Immunoglobulin M / blood
RNA, Viral / blood*
Viral Core Proteins / immunology*

Substances

Biomarkers
Hepatitis Antibodies
Hepatitis C Antibodies
Immunoglobulin G
Immunoglobulin M
RNA, Viral
Viral Core Proteins
nucleocapsid protein, Hepatitis C virus