DALDA (H-Tyr-D-Arg-Phe-Lys-NH2), a potent mu-opioid peptide agonist, affects various patterns of locomotor activities

M E Meyer; B I McLaurin; M E Meyer

doi:10.1016/0091-3057(94)00308-6

DALDA (H-Tyr-D-Arg-Phe-Lys-NH2), a potent mu-opioid peptide agonist, affects various patterns of locomotor activities

Pharmacol Biochem Behav. 1995 May;51(1):149-51. doi: 10.1016/0091-3057(94)00308-6.

Authors

M E Meyer¹, B I McLaurin, M E Meyer

Affiliation

¹ Department of Psychology, University of Florida, Gainesville 32611, USA.

PMID: 7617726
DOI: 10.1016/0091-3057(94)00308-6

Abstract

The central effects of mu-opioid receptor agonist DALDA (ICV 0.00, 0.1, or 1.0 micrograms) were investigated in rats for 120 min on activity monitors. The durations in seconds of horizontal movement time, rearing time, and stereotypy time were measured during 12 consecutive 10-min time blocks. DALDA (ICV, 0.1 and 1.0 micrograms) resulted in biphasic effects, inhibition followed by activation for horizontal movement, rearing, and stereotypy times.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Analgesics / administration & dosage
Analgesics / pharmacology*
Animals
Injections, Intraventricular
Locomotion / drug effects*
Male
Molecular Sequence Data
Motor Activity / drug effects
Oligopeptides / administration & dosage
Oligopeptides / pharmacology*
Rats
Receptors, Opioid, mu / agonists*
Stereotyped Behavior / drug effects

Substances

Analgesics
Oligopeptides
Receptors, Opioid, mu
tyrosyl-arginyl-phenylalanyl-lysinamide