Sphenoid sinusitis is often ignored by doctors, for the sphenoid sinuses are the most neglected paranasal sinuses and sphenoid sinusitis lacks specific symptoms. 58 cases of sphenoid sinusitis were reported in this article. The specific clinical symptoms remain to be deficient. At present, computerized tomography, MRI and telescope help to make accurate evaluation of sphenoid sinus diseases. The endoscopic intranasal surgery for sphenoid sinusitis enables the complicated surgical procedures simple. In our series, most cases (53) are sphenoethmoid sinusitis. The isolated sphenoid sinusitis is rare in clinical practice.