Analysis of the phase shifting effects of gastrin releasing peptide when microinjected into the suprachiasmatic region

Neurosci Lett. 1995 May 19;191(1-2):63-6. doi: 10.1016/0304-3940(95)11559-1.

Abstract

The role of gastrin releasing peptide (GRP) in phase shifting circadian rhythms was investigated. Microinjection of GRP into the suprachiasmatic region (SCN) region produced only small changes in the phase of free-running circadian activity rhythms in hamsters housed in constant darkness. However, co-administration of GRP with vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) produced significantly larger phase delays than GRP alone. These data support the hypothesis that GRP interacts with VIP and PHI within the SCN to induce phase shifts of circadian rhythms.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Circadian Rhythm / drug effects*
  • Cricetinae
  • Darkness
  • Gastrin-Releasing Peptide
  • Gastrins / metabolism*
  • Male
  • Mesocricetus
  • Microinjections
  • Neuropeptide Y / administration & dosage
  • Neuropeptide Y / pharmacology
  • Peptide PHI / pharmacology
  • Peptides / administration & dosage
  • Peptides / pharmacology*
  • Suprachiasmatic Nucleus / drug effects
  • Suprachiasmatic Nucleus / physiology*
  • Vasoactive Intestinal Peptide / pharmacology

Substances

  • Gastrins
  • Neuropeptide Y
  • Peptide PHI
  • Peptides
  • Vasoactive Intestinal Peptide
  • Gastrin-Releasing Peptide