The role of the O-antigen lipopolysaccharide on the colonization in vivo of the germfree chicken gut by Klebsiella pneumoniae

S Camprubí; S Merino; J F Guillot; J M Tomás

doi:10.1006/mpat.1993.1042

The role of the O-antigen lipopolysaccharide on the colonization in vivo of the germfree chicken gut by Klebsiella pneumoniae

Microb Pathog. 1993 Jun;14(6):433-40. doi: 10.1006/mpat.1993.1042.

Authors

S Camprubí¹, S Merino, J F Guillot, J M Tomás

Affiliation

¹ Departamento de Microbiologïa, Universidad de Barcelona, Spain.

PMID: 7692209
DOI: 10.1006/mpat.1993.1042

Abstract

We isolated lipopolysaccharide and capsular polysaccharide (K antigen)-defective mutants from two Klebsiella pneumoniae parental strains, and compared their ability to colonize in vivo the germfree chicken gut. The high-molecular weight lipopolysaccharide (LPS) (O antigen) was found necessary for the colonization while the capsular polysaccharide (K2 or K29) was not of importance.

MeSH terms

Animals
Bacterial Capsules / analysis
Bacterial Capsules / physiology*
Chickens / microbiology*
Digestive System / microbiology
Feces / microbiology
Germ-Free Life
Klebsiella pneumoniae / chemistry*
Klebsiella pneumoniae / pathogenicity
Lipopolysaccharides* / analysis
Mutation
O Antigens
Polysaccharides, Bacterial / analysis
Polysaccharides, Bacterial / physiology*

Substances

Lipopolysaccharides
O Antigens
Polysaccharides, Bacterial