To investigate the prevalene of posterior vitreous detachment (PVD) and PVD with collapse in relation to age in eyes with retinitis pigmentosa (RP), we retrospectively studied the vitreous condition in 218 eyes of 109 patients with RP. Two hundred thirty healthy eyes of 115 subjects served as controls. The prevalence of both PVD and PVD with collapse, respectively, in the first through the sixth decades of life, and the second through the seventh decades was significantly higher in the RP eyes than in the controls (P < .01). Our findings demonstrated the early onset and progression of PVD with age in the eyes with RP as compared with the control eyes.