Glycoprotein B of bovine herpesvirus-1 binds heparin

Virology. 1995 May 10;209(1):230-5. doi: 10.1006/viro.1995.1248.

Abstract

Many members of the herpesvirus family have been shown to bind heparan sulfate on the surface of target cells. A previous report on bovine herpesvirus-1 (BHV-1) glycoprotein interactions indicated that only gC bound to heparin-agarose columns. In this report, we demonstrated that both gC and gB of wild-type BHV-1 bound to heparin-agarose columns and that gC-minus virus infectivity was inhibited by heparin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adsorption
  • Animals
  • Cattle
  • Cell Membrane / virology
  • Cells, Cultured
  • Heparin / metabolism*
  • Herpesvirus 1, Bovine / genetics
  • Herpesvirus 1, Bovine / metabolism*
  • Herpesvirus 1, Bovine / pathogenicity
  • Mutation
  • Protein Binding
  • Viral Envelope Proteins / genetics
  • Viral Envelope Proteins / metabolism*
  • Viral Proteins / genetics
  • Viral Proteins / metabolism

Substances

  • Viral Envelope Proteins
  • Viral Proteins
  • bovine herpesvirus type-1 glycoproteins
  • Heparin