Abstract
Many members of the herpesvirus family have been shown to bind heparan sulfate on the surface of target cells. A previous report on bovine herpesvirus-1 (BHV-1) glycoprotein interactions indicated that only gC bound to heparin-agarose columns. In this report, we demonstrated that both gC and gB of wild-type BHV-1 bound to heparin-agarose columns and that gC-minus virus infectivity was inhibited by heparin.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adsorption
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Animals
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Cattle
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Cell Membrane / virology
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Cells, Cultured
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Heparin / metabolism*
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Herpesvirus 1, Bovine / genetics
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Herpesvirus 1, Bovine / metabolism*
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Herpesvirus 1, Bovine / pathogenicity
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Mutation
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Protein Binding
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Viral Envelope Proteins / genetics
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Viral Envelope Proteins / metabolism*
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Viral Proteins / genetics
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Viral Proteins / metabolism
Substances
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Viral Envelope Proteins
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Viral Proteins
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bovine herpesvirus type-1 glycoproteins
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Heparin