Abstract
In a cohort of victims of traumatic brain injury, 18 out of 50 patients had a plasma tumour necrosis factor (TNF) concentration above 2 pg/ml within 24 h of injury (mean 12.19, SD 45.96 pg/ml). Twenty-six had CSF samples available of which 17 demonstrated TNF concentrations above 1 pg/ml (mean 3.98, SD 3.61 pg/ml). We conclude that traumatized brain parenchyma is a significant source of TNF activity and implicate the cytokine in cellular metabolic derangements following head injury.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Blood-Brain Barrier / physiology
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Brain Damage, Chronic / cerebrospinal fluid*
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Brain Damage, Chronic / diagnosis
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Brain Damage, Chronic / surgery
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Brain Edema / cerebrospinal fluid
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Brain Edema / diagnosis
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Brain Edema / surgery
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Brain Injuries / cerebrospinal fluid*
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Brain Injuries / diagnosis
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Brain Injuries / surgery
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Cerebral Hemorrhage / cerebrospinal fluid
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Cerebral Hemorrhage / diagnosis
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Cerebral Hemorrhage / surgery
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Child
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Child, Preschool
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Enzyme-Linked Immunosorbent Assay
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Female
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Glasgow Coma Scale
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Humans
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Male
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Middle Aged
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Tumor Necrosis Factor-alpha / cerebrospinal fluid*
Substances
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Tumor Necrosis Factor-alpha