Oesophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1

J Adélaide; G Monges; C Dérdérian; J F Seitz; D Birnbaum

doi:10.1038/bjc.1995.13

Oesophageal cancer and amplification of the human cyclin D gene CCND1/PRAD1

Br J Cancer. 1995 Jan;71(1):64-8. doi: 10.1038/bjc.1995.13.

Authors

J Adélaide¹, G Monges, C Dérdérian, J F Seitz, D Birnbaum

Affiliation

¹ Laboratoire de Biologie des Tumeurs, Institut Paoli-Calmettes, Marseille, France.

Abstract

The human CCND1/PRAD1 gene, located in the 11q13 chromosomal region, encodes a cyclin D protein with potential oncogenic capacity and is involved in several human malignancies. The amplification and expression status of CCND1 was investigated in a series of oesophageal tumours. CCND1 is amplified in 54% and overexpressed in 63% of the tumours of the squamous cell type.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosomes, Human, Pair 11
Cyclins / genetics*
Esophageal Neoplasms / genetics*
Esophageal Neoplasms / pathology
Gene Amplification*
Humans

Substances

Cyclins