Cloning of a new member of the TGF-beta family: a putative new activin beta C chain

Biochem Biophys Res Commun. 1995 Jan 17;206(2):608-13. doi: 10.1006/bbrc.1995.1086.

Abstract

The complete amino acid sequence of a new member of the TGF-beta superfamily has been determined through initial degenerate PCR, subsequent cloning and nucleotide sequencing of the human cDNA. Amino acid homology comparison among members of this superfamily suggests it to be a new member of the activin/inhibin subgroup. The proposed mature part of the precursor shows 53% amino acid identity to the activin beta B and 51% identity to the activin beta A chain whereas beta A and beta B show an identity of 64% to each other.

Publication types

  • Comparative Study

MeSH terms

  • Activins
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chickens
  • Cloning, Molecular
  • DNA Primers
  • Drosophila
  • Growth Substances / biosynthesis*
  • Humans
  • Inhibins / biosynthesis*
  • Inhibins / chemistry
  • Inhibins / genetics
  • Macromolecular Substances
  • Mice
  • Molecular Sequence Data
  • Phylogeny*
  • Polymerase Chain Reaction
  • Sequence Homology, Amino Acid
  • Transforming Growth Factor beta / biosynthesis*
  • Transforming Growth Factor beta / chemistry
  • Transforming Growth Factor beta / genetics
  • Xenopus

Substances

  • DNA Primers
  • Growth Substances
  • Macromolecular Substances
  • Transforming Growth Factor beta
  • Activins
  • Inhibins

Associated data

  • GENBANK/X82540