Physical mapping of 3 candidate tumor suppressor genes relative to Beckwith-Wiedemann syndrome associated chromosomal breakpoints at 11p15.3

E Redeker; M Alders; J M Hoovers; C W Richard 3rd; A Westerveld; M Mannens

doi:10.1159/000133917

Physical mapping of 3 candidate tumor suppressor genes relative to Beckwith-Wiedemann syndrome associated chromosomal breakpoints at 11p15.3

Cytogenet Cell Genet. 1995;68(3-4):222-5. doi: 10.1159/000133917.

Authors

E Redeker¹, M Alders, J M Hoovers, C W Richard 3rd, A Westerveld, M Mannens

Affiliation

¹ Institute of Human Genetics, University of Amsterdam, The Netherlands.

PMID: 7842740
DOI: 10.1159/000133917

Abstract

A physical map encompassing the 3 Mb region containing the breakpoints of two Beckwith-Wiedemann Syndrome patients at chromosome band 11p15.3 is presented. The candidate tumor suppressor genes WEE1, ST5, and rhombotin, are positioned on this map relative to these Beckwith-Wiedemann syndrome translocation and inversion breakpoints.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Beckwith-Wiedemann Syndrome / genetics*
Chromosome Aberrations*
Chromosome Mapping*
Chromosomes, Human, Pair 11*
DNA Probes
Genes, Tumor Suppressor / genetics*
Humans
In Situ Hybridization, Fluorescence

Substances

DNA Probes