Abstract
Fourteen cancer patients treated with cisplatin received repeated infusions of tropisetron on-demand in conjunction with emesis. In subsequent chemotherapy courses, prophylactic tropisetron was given in a dose identical to the cumulated dose in study course 1. Tropisetron in study course 1 abolished emesis after 7.5 min (5 mg). Duration of effect was more than 7 h in 50% of the patients. No relationship between dose and duration of effect was seen. After study course 2, eight of 10 patients preferred prophylactic tropisetron. Two patients with hypertension had a severe increase in blood pressure probably related to tropisetron. It is concluded that tropisetron has an instant and lasting effect on nausea and vomiting when given on-demand. The majority of patients, however, prefer prophylactic treatment. Hypertension may be a side effect from tropisetron and caution should be displayed in hypertensive patients.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Antiemetics / administration & dosage
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Antiemetics / pharmacokinetics
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Antiemetics / therapeutic use*
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Cisplatin / adverse effects*
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Cisplatin / therapeutic use*
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Dose-Response Relationship, Drug
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Female
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Head and Neck Neoplasms / complications
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Head and Neck Neoplasms / drug therapy*
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Humans
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Indoles / administration & dosage
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Indoles / pharmacokinetics
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Indoles / therapeutic use*
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Male
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Middle Aged
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Nausea / chemically induced*
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Nausea / drug therapy*
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Nausea / prevention & control
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Ovarian Neoplasms / complications
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Ovarian Neoplasms / drug therapy*
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Serotonin Antagonists / administration & dosage
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Serotonin Antagonists / pharmacokinetics
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Serotonin Antagonists / therapeutic use*
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Tropisetron
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Vomiting / chemically induced*
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Vomiting / drug therapy*
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Vomiting / prevention & control
Substances
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Antiemetics
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Indoles
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Serotonin Antagonists
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Tropisetron
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Cisplatin