Abstract
Experimental data indicate that EtOH extract of Acanthopanax giraldii (EAGH) has pronounced analgesic action and reduces not only high temperature induced by proteinic jelly, but also normal body temperature in rabbits. However no effect was observed on the fever induced by choleraic vaccine in rabbits. The acute ip LD50 of EAGH in mice was 73.34 +/- 7.29 g/kg (crude drug). In prolonged toxicity test on rats no harmful effects on body weight, blood picture, liver and kidney functions were observed.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Anti-Inflammatory Agents, Non-Steroidal / toxicity
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Body Temperature / drug effects*
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Cholera Vaccines
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Drugs, Chinese Herbal / pharmacology*
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Drugs, Chinese Herbal / therapeutic use
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Drugs, Chinese Herbal / toxicity
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Female
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Fever / drug therapy*
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Fever / etiology
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Male
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Mice
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Pain Threshold / drug effects*
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Rabbits
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Random Allocation
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Rats
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cholera Vaccines
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Drugs, Chinese Herbal