Abstract
No curative drug against HIV has yet been found, despite enormous efforts aimed at reverse transcriptase and a variety of other targets. The long terminal repeat (LTR) of HIV-1 has recently become a promising site for antiviral action. This article briefly summarizes information on the nature of this target and potential anti-LTR expression drugs.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Acquired Immunodeficiency Syndrome / drug therapy*
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Antiviral Agents / pharmacology*
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Antiviral Agents / therapeutic use
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Base Sequence
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HIV Long Terminal Repeat / genetics*
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HIV-1 / drug effects*
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HIV-1 / genetics
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Humans
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Models, Biological
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Molecular Sequence Data
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Transcription, Genetic / drug effects*
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Transcriptional Activation / drug effects