Abstract
Amphiphilic substances may stimulate cellular events through direct activation of G-proteins. The present experiments indicate that several amphiphilic sweeteners and the bitter tastant, quinine, activate transducin and Gi/Go-proteins. Concentrations of taste substances required to activate G-proteins in vitro correlated with those used to elicit taste. These data support the hypothesis that amphiphilic taste substances may elicit taste through direct activation of G-proteins.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cattle
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Enzyme Activation
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GTP Phosphohydrolases / metabolism
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GTP-Binding Proteins / metabolism*
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Intercellular Signaling Peptides and Proteins
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Peptides
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Phosphatidylcholines
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Phospholipids / pharmacology
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Sweetening Agents / pharmacology*
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Taste* / drug effects
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Wasp Venoms / pharmacology
Substances
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Intercellular Signaling Peptides and Proteins
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Peptides
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Phosphatidylcholines
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Phospholipids
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Sweetening Agents
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Wasp Venoms
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asolectin
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mastoparan
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GTP Phosphohydrolases
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GTP-Binding Proteins