Mammalian retrovirus-associated RNase H is virus coded

J Virol. 1978 Sep;27(3):823-5. doi: 10.1128/JVI.27.3.823-825.1978.

Abstract

RNase H of a temperature-sensitive mutant of Rauscher murine leukemia virus is thermolabile, establishing this activity as a virus-coded function of the mammalian type C virus reverse transcriptase.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cell Line
  • Hot Temperature
  • Mutation
  • RNA-Directed DNA Polymerase / metabolism
  • Rauscher Virus / enzymology*
  • Rauscher Virus / genetics
  • Rauscher Virus / growth & development
  • Ribonucleases / genetics
  • Ribonucleases / metabolism*
  • Virus Replication

Substances

  • RNA-Directed DNA Polymerase
  • Ribonucleases