Abstract
Intracytoplasmic leukovirus-like bodies were found in the cells and culture medium of a T-cell lymphoblast line established from a leukaemic patient. When the cells were lethally irradiated and added to normal bone-marrow cells the latter were transformed into continuous replication and produced the same types of virus-like particle.
MeSH terms
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Adult
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Bone Marrow / pathology*
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Cell Division
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Cell Line
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Cell Transformation, Neoplastic / pathology*
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Cell Transformation, Viral*
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Female
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Golgi Apparatus / microbiology
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Humans
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In Vitro Techniques
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Inclusion Bodies, Viral
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Leukemia, Monocytic, Acute / pathology*
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Leukemia, Monocytic, Acute / transmission
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Male
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Microscopy, Electron
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Middle Aged
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Radiation Dosage
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Retroviridae / isolation & purification*
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Staining and Labeling
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T-Lymphocytes / pathology*
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T-Lymphocytes / radiation effects