A new pharmophoric model for 5-HT reuptake-inhibitors: differentiation of amphetamine analogues

Pharm Acta Helv. 1994 May;68(4):235-44. doi: 10.1016/0031-6865(94)90054-x.

Abstract

A pharmacophoric model for 5-HT reuptake-inhibitors was developed using the pharmacophore elements geometry and MEP (Molecular Electrostatic Potential) by the method of active analogue approach. This model is characterized by: (1) a protonated basic nitrogen separated by 610 pm from the center of an aromatic system and 920 pm from an electronegative substituent of this aromatic system, (2) a region with n- and/or pi-electrons along the axis substituent-aromatic system-nitrogen atom, (3) an aliphatic side chain which joins the region of the n- and/or pi-electrons with the nitrogen atom, (4) an additional aromatic group at right angles to the pharmacophoric aromatic group below the protonated nitrogen and (5) a forbidden region on the pharmacophore which leads to a deviation of the allowed tubular orientation of the ligand. The pharmacophore model enables a differentiation of the entactogenic, hallucinogenic and stimulating arylalkanamines. The theoretical considerations are confirmed by a postulated intramolecular H-bonding in the active conformation of the selective 5-HT reuptake-inhibitor, citalopram (12 in Fig. 2), which could be proved by NMR- and IR-spectroscopic measurements.

MeSH terms

  • Amphetamines / chemistry*
  • Amphetamines / pharmacology*
  • Models, Molecular
  • Selective Serotonin Reuptake Inhibitors / chemistry*
  • Selective Serotonin Reuptake Inhibitors / pharmacology*

Substances

  • Amphetamines
  • Serotonin Uptake Inhibitors