Abstract
Three new bromotyrosine-derived alkaloids, aplysinamisines I [4], II [5], and III [6], were isolated from the sponge Aplysina cauliformis collected in Puerto Rico and their chemical structures elucidated on the basis of spectroscopic methods. Compounds 4-6 showed marginal antimicrobial activity, and aplysinamisines II [5] and III [6] displayed modest cytotoxicity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Bacteria / drug effects
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Oxazoles / chemistry*
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Oxazoles / pharmacology
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Porifera / metabolism*
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Spiro Compounds / chemistry*
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Spiro Compounds / pharmacology
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Tumor Cells, Cultured
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Tyrosine / analogs & derivatives*
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Tyrosine / chemistry
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents
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Oxazoles
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Spiro Compounds
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aplysinamisine I
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aplysinamisine II
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aplysinamisine III
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Tyrosine
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3,5-dibromotyrosine