Eupenifeldin, a novel cytotoxic bistropolone from Eupenicillium brefeldianum

J Antibiot (Tokyo). 1993 Jul;46(7):1082-8. doi: 10.7164/antibiotics.46.1082.

Abstract

Eupenifeldin was isolated from cultures of Eupenicillium brefeldianum ATCC 74184 by extraction and crystallization. The compound was identified as a pentacyclic bistropolone on the basis of spectral data and its complete structure was established by single-crystal X-ray analysis. The compound is cytotoxic against the HCT-116 cell line and has in vivo antitumor activity in the P388 leukemia model.

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic* / chemistry
  • Antibiotics, Antineoplastic* / isolation & purification
  • Antibiotics, Antineoplastic* / pharmacology
  • Ascomycota / metabolism
  • Chemical Phenomena
  • Chemistry, Physical
  • Drug Screening Assays, Antitumor
  • Fermentation
  • Humans
  • Mice
  • Molecular Structure
  • Tropolone / analogs & derivatives*
  • Tropolone / chemistry
  • Tropolone / isolation & purification
  • Tropolone / pharmacology

Substances

  • Antibiotics, Antineoplastic
  • eupenifeldin
  • Tropolone