Bullous disease in children can be confusing clinically and challenging to mange. Five groups of autoimmune bullous disease are discussed with emphasis on unique features in children. Pemphigus (vulgaris, foliaceus, neonatal), pemphigoid (bullous and cicatricial), dermatitis herpetiformis, linear IgA dermatosis, and epidermolysis bullosa acquisita are uncommon pediatric disorders. A high index of suspicion is necessary to diagnose and treat these conditions without delay.