Inhibition of pancreatic islet beta cell function by tumor necrosis factor is blocked by a soluble tumor necrosis factor receptor

Transplant Proc. 1993 Feb;25(1 Pt 2):865-6.

Authors

A C Farney¹, E Xenos, D E Sutherland, M Widmer, E Stephanian, M J Field, D B Kaufman, R B Stevens, B Blazar, J Platt, et al.

Affiliation

¹ Department of Surgery, University of Minnesota, Minneapolis.

PMID: 8382881

No abstract available

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Diabetes Mellitus, Experimental / physiopathology*
Diabetes Mellitus, Experimental / therapy
Humans
Immunoglobulin Fc Fragments / genetics
Immunoglobulin G / genetics
In Vitro Techniques
Insulin / metabolism*
Insulin Secretion
Islets of Langerhans / drug effects*
Islets of Langerhans / metabolism
Islets of Langerhans / physiology
Mice
Mice, Inbred C57BL
Receptors, Cell Surface / genetics
Receptors, Cell Surface / physiology*
Receptors, Tumor Necrosis Factor
Recombinant Fusion Proteins / therapeutic use
Tumor Necrosis Factor-alpha / pharmacology*

Substances

Immunoglobulin Fc Fragments
Immunoglobulin G
Insulin
Receptors, Cell Surface
Receptors, Tumor Necrosis Factor
Recombinant Fusion Proteins
Tumor Necrosis Factor-alpha

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