cDNA cloning and pharmacological characterization of an opioid receptor with high affinities for kappa-subtype-selective ligands

FEBS Lett. 1993 Sep 6;330(1):77-80. doi: 10.1016/0014-5793(93)80923-i.

Abstract

The amino acid sequence of a rat opioid receptor, designated as ROR-D, has been deduced by cloning and sequencing the cDNA. The ROR-D expressed from the cDNA exhibits high affinities for ligands selective for the opioid receptor kappa-subtype and low affinities for ligands selective for the delta- and mu-subtypes. RNA blot hybridization analysis indicated that ROR-D mRNA is distributed in cerebrum and brainstem but not in cerebellum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Brain / metabolism
  • Cells, Cultured
  • Cloning, Molecular
  • DNA
  • Ligands
  • Molecular Sequence Data
  • Rats
  • Rats, Wistar
  • Receptors, Opioid, delta / drug effects
  • Receptors, Opioid, delta / metabolism
  • Receptors, Opioid, kappa / drug effects
  • Receptors, Opioid, kappa / genetics*
  • Receptors, Opioid, kappa / metabolism
  • Receptors, Opioid, mu / drug effects
  • Receptors, Opioid, mu / metabolism
  • Sequence Homology, Amino Acid

Substances

  • Ligands
  • Receptors, Opioid, delta
  • Receptors, Opioid, kappa
  • Receptors, Opioid, mu
  • DNA

Associated data

  • GENBANK/D16534