Alternative donor transplants for leukemia. Scientific Advisory Committee of the International Bone Marrow Transplant Registry

Bone Marrow Transplant. 1993:11 Suppl 1:66-7.

Abstract

We analyzed transplant outcome in more than 2,500 recipients of alternative donor and HLA-identical sibling transplants. These data indicate: (1) results of alternative donor transplants are inferior to HLA-identical sibling transplants; (2) zero HLA-antigen disparate unrelated and one HLA-antigen disparate related donors have comparable results; (3) amongst unrelated donors, zero and one HLA-antigen disparity has comparable results; and (4), amongst related transplants, two HLA-antigen disparate transplants fare worse than one HLA-antigen disparate transplants. These data should be useful in deciding when to use an alternative donor and selecting the best donor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bone Marrow Transplantation* / immunology
  • HLA Antigens / analysis
  • HLA Antigens / immunology
  • Histocompatibility / immunology
  • Humans
  • Leukemia / surgery*
  • Multivariate Analysis
  • Tissue Donors

Substances

  • HLA Antigens