Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21

Am J Hum Genet. 1993 Apr;52(4):767-76.

Abstract

In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at theta = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Breast Neoplasms / genetics*
  • Chromosome Mapping / methods*
  • Chromosomes, Human, Pair 17*
  • DNA, Neoplasm / analysis
  • DNA, Satellite / analysis
  • Family Health
  • Female
  • Genetic Linkage
  • Genetic Markers
  • Genetic Variation
  • Humans
  • Lod Score
  • Male
  • Middle Aged
  • Neoplastic Syndromes, Hereditary / genetics
  • Ovarian Neoplasms / genetics*
  • Pedigree
  • Polymorphism, Genetic
  • Proto-Oncogenes*
  • Recombination, Genetic

Substances

  • DNA, Neoplasm
  • DNA, Satellite
  • Genetic Markers