ADH and ALDH genotype profiles in Caucasians with alcohol-related problems and controls

F J Gilder; S Hodgkinson; R M Murray

doi:10.1111/j.1360-0443.1993.tb00825.x

ADH and ALDH genotype profiles in Caucasians with alcohol-related problems and controls

Addiction. 1993 Mar;88(3):383-8. doi: 10.1111/j.1360-0443.1993.tb00825.x.

Authors

F J Gilder¹, S Hodgkinson, R M Murray

Affiliation

¹ Department of Psychological Medicine, Institute of Psychiatry, London, UK.

PMID: 8461855
DOI: 10.1111/j.1360-0443.1993.tb00825.x

Abstract

Eighty-two Caucasian patients receiving treatment for alcohol-related problems and eighty four controls were DNA typed for variants in the alcohol dehydrogenase (ADH2 and ADH3) and mitochondrial aldehyde dehydrogenase (ALDH2) gene loci. No association was observed between individual, or combined gene frequencies and the presence of alcohol-related problems.

MeSH terms

Adult
Alcohol Dehydrogenase / genetics*
Alcoholism / genetics*
Aldehyde Dehydrogenase / genetics*
Female
Gene Frequency
Genotype*
Humans
Isoenzymes / genetics*
Male
Middle Aged
Polymerase Chain Reaction
Risk Factors
United Kingdom

Substances

Isoenzymes
Alcohol Dehydrogenase
Aldehyde Dehydrogenase