A 54-yr-old woman with cutaneous nodules showed accumulation of 67Ga- and 111In-labeled leukocytes in skin nodules, bilateral pulmonary hilar lymph nodes and the right upper mediastinum. Biopsy of the skin nodule proved epithelioid cell granuloma with moderate lymphocyte infiltration peripherally consistent with sarcoidosis. Sarcoidosis is a potential pitfall in labeled leukocyte imaging, which is performed for detecting a febrile focus.