The sequence-specific nuclear matrix binding factor F6 is a chicken GATA-like protein

Mol Gen Genet. 1993 Apr;238(3):309-14. doi: 10.1007/BF00291988.

Abstract

The sequence-specific DNA-binding protein factor F6, which binds upstream of the cluster of the chicken alpha-globin genes, has previously been found to interact with a DNA fragment containing a replication origin and a nuclear matrix binding site. This protein has been partially characterized. Based on its molecular weight and binding affinity, F6 belongs to a family of GATA proteins, the chicken equivalent of transcription factor NFE-1. An oligonucleotide including the binding site for F6 competes for binding of the above-mentioned DNA fragment to the nuclear matrix. This indicates an involvement of this protein in the interaction between DNA and the nuclear matrix.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Nuclear
  • Base Sequence
  • Cell Line, Transformed
  • Chickens
  • DNA-Binding Proteins / drug effects
  • DNA-Binding Proteins / isolation & purification
  • DNA-Binding Proteins / physiology*
  • Distamycins / pharmacology
  • Erythroid-Specific DNA-Binding Factors
  • GATA1 Transcription Factor
  • Molecular Sequence Data
  • Nuclear Matrix / chemistry*
  • Nuclear Proteins / drug effects
  • Nuclear Proteins / isolation & purification
  • Nuclear Proteins / physiology*
  • Regulatory Sequences, Nucleic Acid
  • Transcription Factors

Substances

  • Antigens, Nuclear
  • DNA-Binding Proteins
  • Distamycins
  • Erythroid-Specific DNA-Binding Factors
  • GATA1 Transcription Factor
  • Nuclear Proteins
  • Transcription Factors
  • stallimycin