Abstract
The efficacy of rifampin in eliminating Staphylococcus aureus colonization was evaluated in a pediatric peritoneal dialysis population. Six children with documented nasal colonization were treated for 7 days with rifampin and cloxacillin. Although antimicrobial therapy eliminated nasal carriage in all patients, recolonization occurred in 66%. Exit site colonization proved difficult to eradicate with negative cultures documented in only 3 of 5 children after rifampin/cloxacillin therapy. Although S. aureus carriage is a risk factor for S. aureus infections, efforts to eradicate carriage with rifampin are hindered by rapid recolonization.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibiotics, Antitubercular / therapeutic use*
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Catheters, Indwelling / microbiology*
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Child
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Cloxacillin / therapeutic use
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Colony Count, Microbial
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Drug Resistance, Microbial
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Drug Therapy, Combination / therapeutic use
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Female
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Humans
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Male
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Nose / microbiology*
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Penicillins / therapeutic use
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Peritoneal Dialysis, Continuous Ambulatory / adverse effects*
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Peritoneal Dialysis, Continuous Ambulatory / instrumentation
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Peritonitis / drug therapy
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Peritonitis / microbiology*
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Rifampin / therapeutic use*
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / isolation & purification
Substances
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Antibiotics, Antitubercular
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Penicillins
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Cloxacillin
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Rifampin