The X-linked methylated DNA binding protein, Mecp2, is subject to X inactivation in the mouse

Mamm Genome. 1995 Aug;6(8):491-2. doi: 10.1007/BF00356163.

Abstract

DNA methylation at the promoter region of X-linked genes is associated with the maintenance of X inactivation in mammals. One of the methylated DNA binding proteins, MECP2, that binds to methylated bases in DNA is encoded by a gene (Mecp2) located on the mouse X Chromosome (Chr). To determine whether this gene was expressed from the inactive X Chr, and X-autosome translocation (T(X;16)16H) system in which expression from the Mecp2 allele on the inactive X Chr could be assayed was used. Results from these experiments indicate that Mecp2 is subject to X inactivation in mouse.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Chromosomal Proteins, Non-Histone*
  • DNA Primers
  • DNA-Binding Proteins / genetics*
  • Dosage Compensation, Genetic*
  • Female
  • Genetic Linkage*
  • Methyl-CpG-Binding Protein 2
  • Methylation
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Muridae
  • Repressor Proteins*
  • Translocation, Genetic
  • X Chromosome*

Substances

  • Chromosomal Proteins, Non-Histone
  • DNA Primers
  • DNA-Binding Proteins
  • Mecp2 protein, mouse
  • Methyl-CpG-Binding Protein 2
  • Repressor Proteins