Abstract
Thirty-six cases of hepatic toxicity associated with felbamate therapy have been collected by the Food and Drug Administration. Five patients died. We describe a case of massive acute hepatic necrosis and death within 40 days of initiation of felbamate therapy for a generalized tonic-clonic seizure disorder. We describe the clinical and histopathologic features.
MeSH terms
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Anticonvulsants / adverse effects*
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Chemical and Drug Induced Liver Injury*
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Epilepsy, Tonic-Clonic / drug therapy*
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Fatal Outcome
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Felbamate
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Female
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Humans
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Liver / drug effects
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Liver / pathology*
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Liver Diseases / pathology
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Liver Diseases / physiopathology
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Liver Function Tests
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Middle Aged
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Necrosis
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Phenylcarbamates
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Propylene Glycols / adverse effects*
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United States
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United States Food and Drug Administration
Substances
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Anticonvulsants
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Phenylcarbamates
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Propylene Glycols
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Felbamate