Abstract
1. VP and OT mediate their wealth of effects via 4 receptor subtypes V1a, V1b, V2, and OT receptors. 2. We here review recent insights in the pharmacological properties, structure activity relationships, species differences in ligand specificity, expression patterns, and signal transduction of VP/OT receptor. 3. Furthermore, the existence of additional VP/OT receptor subtypes is discussed.
MeSH terms
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Amino Acid Sequence
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Animals
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Humans
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Ligands
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Models, Neurological*
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Molecular Sequence Data
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Phylogeny
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Protein Structure, Secondary
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Receptors, Oxytocin / chemistry
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Receptors, Oxytocin / physiology*
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Receptors, Vasopressin / chemistry
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Receptors, Vasopressin / physiology*
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Sequence Homology, Amino Acid
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Signal Transduction*
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Species Specificity
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Structure-Activity Relationship
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Substrate Specificity
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Vasopressins / pharmacology
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Vasopressins / physiology*
Substances
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Ligands
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Receptors, Oxytocin
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Receptors, Vasopressin
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Vasopressins